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. 2022 Nov 19;4(6):fcac291. doi: 10.1093/braincomms/fcac291

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Published by Oxford University Press on behalf of the Guarantors of Brain 2022. This work is written by (a) US Government employee(s) and is in the public domain in the US.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

PMC Copyright notice

Parabrachial nucleus (PBP) seed identified the functional circuit consequences of changes in nAChR binding. (A) Using the PBP as a ‘seed’, we identified a cluster within the NAc whose connectivity changed as a function of the exposure age × dose interaction. (B) Extracted rsFC Z values reveal higher PBP-NAc connectivity in adolescent nicotine exposed rats, comparable to adult saline exposed rats. The significance threshold was set to p_corrected < 0.05 (p_uncorrected < 0.01, cluster size > 7 voxels). Note that extracted data are for illustrative purposes only and no statistical comparisons were performed between groups. Bars represent mean ± SEM, and individual data points represent rsFC of a brain region for an individual rat.