Figure 7.

The identified NAc cluster seed identified the functional circuit consequences of changes in nAChR binding. (A) In an exploratory analysis using the NAc identified in Fig. 6A as a ‘seed’, we observed changes in connectivity as a function of the exposure age × dose interaction across the sensorimotor cortex (B+C) and thalamus (D, E and F). All regions showed heightened connectivity with adolescent exposure to nicotine, comparable to that observed in adult saline exposed rats. The significance threshold was set to p_corrected < 0.05 (p_uncorrected < 0.01, cluster size > 7 voxels). Note that extracted data are for illustrative purposes only, and no statistical comparisons were performed between groups. Bars represent mean ± SEM, and individual data points represent rsFC of a brain region for an individual rat.