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Target engagement and cellular effects of select compounds, 23, 24, 26, and 30 in MM.1S cells. (A) Cellular thermal shift assay after 1 h treatment with compounds at indicated concentrations. (B) Western blots for c-Myc after 6 h treatment with compounds at same concentrations as in (A). Data is representative of three replicate experiments, see Supporting Information for uncropped images.
