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. Author manuscript; available in PMC: 2022 Nov 23.
Published in final edited form as: J Med Chem. 2022 Jan 10;65(3):2342–2360. doi: 10.1021/acs.jmedchem.1c01779

Table 5.

Kinase Affinity against p38α with p-R Substituent

graphic file with name nihms-1848605-t0012.jpg
compd R size of R (Å3) X Kd (nM)a
1 F 13.3 N 0.4725
SB-284851-BT F 13.3 O 4128
2 CF3 39.829 N 260
UMN627 1900
5 I 32.530 N 100
7 I 32.530 O 1500
a

Kd values were determined by KINOMEscan from Eurofins. Data represents the mean of two experimental replicates.