Table 3.
Longitudinal association of demographic characteristics and endocrine parameters with hypertension improvement after the adrenalectomy among patients with subclinical hypercortisolisma
| Outcome | Hypertension improvement after the adrenalectomy | |
|---|---|---|
| Parameters | Adjusted risk difference (95% CI) | P |
| Age | +2.36% (1.08-3.64) | 0.001 |
| Sex (female) | −11.32% (−61.37 to 38.73) | 0.64 |
| Body mass index | −5.08% (−10.29 to 0.13) | 0.06 |
| Systolic blood pressure | −0.67% (−1.77 to 0.43) | 0.22 |
| Serum potassium | −0.06% (−31.84 to 31.71) | 1.00 |
| eGFR | +0.53% (−0.36 to 1.42) | 0.23 |
| Tumor size | +0.79% (−1.35 to 2.93) | 0.45 |
| F, 8:00 Amb,c | −2.81% (−7.43 to 1.81) | 0.22 |
| PAC, 8:00 Amb | +1.45% (0.35-2.55) | 0.01 |
Abbreviations: eGFR, estimated glomerular filtration rate; F, serum cortisol; PRA, plasma renin activity; PAC, plasma aldosterone concentration.
Analysis was not performed for patients with overt hypercortisolism because only 2/18 cases failed to show improved hypertension after the adrenalectomy.
ACTH and PRA were not included in the main model because they have strong correlation with F and PAC, respectively (ie, multicollinearity). The results did not change when additionally adjusting for ACTH and PRA.
The results did not change when we replaced F at 8:00 Am with F after DST (Supplementary Table S3).