Table 3.
Diagnostic Accuracy of CAP for the Detection of Hepatic Steatosis
| AUROC (95% CI) | Cutoff (dB/m) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|---|
| Detection of MRI-PDFF ≥5% | ||||||
| CAP XL probe | ||||||
| Threshold for 90% sensitivity | 0.836 (0.72–0.89) | 261.4 | 90 | 50.0 | 79.5 | 72.7 |
| Optimal threshold | 294 | 75.0 | 78.1 | 87.9 | 59.5 | |
| Threshold for 90% specificity | 316 | 58.8 | 90 | 90.9 | 50.0 | |
| CAP XL probe | ||||||
| Threshold for 90% sensitivity | 0.858 (0.73–0.90) | 281.4 | 90 | 65.6 | 84.9 | 77.8 |
| Optimal threshold | 307 | 73.5 | 75.0 | 86.2 | 57.1 | |
| Threshold for 90% specificity | 323.8 | 61.8 | 90 | 91.3 | 51.9 | |
| Detection of MRI-PDFF ≥10% | ||||||
| CAP M probe | ||||||
| Threshold for 90% sensitivity | 0.886 (0.80–0.94) | 293.6 | 90 | 70.8 | 73.3 | 69.2 |
| Optimal threshold | 311 | 79.2 | 84.6 | 82.6 | 81.5 | |
| Threshold for 90% specificity | 326.8 | 58.3 | 90 | 82.4 | 69.7 | |
| CAP XL probe | ||||||
| Threshold for 90% sensitivity | 0.93 (0.86–0.97) | 314.2 | 90 | 82.7 | 83.0 | 91.5 |
| Optimal threshold | 322 | 83.3 | 86.5 | 85.1 | 84.9 | |
| Threshold for 90% specificity | 323.8 | 83.3 | 90 | 87.0 | 85.2 |
AUROC, area under the receiver-operating characteristic curve; CAP, controlled attenuation parameter; CI, confidence of interval; MRI-PDFF, magnetic resonance imaging–proton density fat fraction; NPV, negative predictive value; PPV, positive predictive value.