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. 2022 Nov 23;17(11):e0276824. doi: 10.1371/journal.pone.0276824

Table 1. Maternal characteristics by prenatal cannabis use, British Columbia, Ontario and Newfoundland and Labrador 2012–2019.

Maternal characteristics Cannabis use No cannabis use p-value
(N = 20,410) (N = 1,031,360)
n % n %
Fiscal Yeara
    2012/2013 2,187 1.5 142,313 98.5 <0.0001
    2013/2014 2,310 1.6 142,687 98.4
    2014/2015 2,788 1.9 142,017 98.1
    2015/2016 2,782 1.8 150,051 98.2
    2016/2017 3,129 2.1 148,222 97.9
    2017/2018 3,271 2.2 147,695 97.8
    2018/2019 3,607 2.5 143,360 97.6
Maternal age
    <20 2,329 11.4 15,859 1.5 <0.0001
    20–24 6,516 31.9 104,691 10.2
    25–29 5,997 29.4 288,020 27.9
    30–34 3,880 19.0 390,930 37.9
    35–39 1,456 7.1 195,834 19.0
    ≥40 232 1.1 36,026 3.5
Pre-pregnancy Body Mass Index (kg/m2)b
    Underweight (<18.5) 1,733 10.1 52,055 5.8 <0.0001
    Normal weight (18.5–24.9) 8,662 50.6 484,620 53.9
    Overweight (25–29.9) 3,584 20.9 208,563 23.2
    Obese (≥30) 3,148 18.4 154,274 17.2
    Missing 3,283 16.1 131,848 12.8
Rural residence 4,103 20.1 113,580 11.0 <0.0001
Neighborhood income
    Lowest quintile 6,987 34.2 187,459 18.2 <0.0001
    Medium-low quintile 4,607 22.6 193,627 18.8
    Middle quintile 3,962 19.4 222,405 21.6
    Medium-high quintile 3,258 16.0 246,890 23.9
    Highest quintile 1,596 7.8 180,979 17.6
Nulliparous 11,518 56.4 440,622 42.7 <0.0001
Infant sex
    Female 9,939 48.7 503,829 48.9 0.9
    Male 10,469 51.3 527,446 51.1
Prenatal tobacco use 11,232 55.0 80,379 7.8 <0.0001
Prenatal alcohol use 2,768 13.6 17,417 1.7 <0.0001
Other substance usec 2,667 13.1 9,574 0.9 <0.0001
Pre-existing diabetes 118 0.6 5,834 0.6 0.8
Gestational diabetes 986 4.8 66,991 6.5 <0.0001
Pre-existing hypertension 82 0.4 4,750 0.5 0.2
Gestational hypertension 616 3.0 30,375 3.0 0.5
Pre-eclampsia/Eclampsia 445 2.2 20,153 2.0 0.02

Note: Includes pregnant individuals who delivered both live and stillbirths.

a Frequencies shown for cannabis use by each fiscal year.

b Frequencies shown exclude missing values due to 13% missing in the total sample.

c Includes solvents, cocaine, methadone, heroin and opioids.