Table 2.
Multivariable Cox Proportional Hazard Models for Outcomes
| IL‐6 quintile | HR (95% CI) adjusted for IL‐6 | P value | HR (95% CI) adjusted for all covariates* | P value |
|---|---|---|---|---|
| Death | ||||
| Q1 | Reference | Reference | ||
| Q2 | 1.71 (1.29–2.26) | <0.001 | 1.34 (0.99–1.83) | 0.06 |
| Q3 | 2.59 (1.99–3.37) | <0.001 | 2.03 (1.42–2.91) | <0.001 |
| Q4 | 3.38 (2.61–4.37) | <0.001 | 2.54 (1.65–3.92) | <0.001 |
| Q5 | 4.82 (3.76–6.18) | <0.001 | 4.11 (2.48–6.80) | <0.001 |
| CVD composite | ||||
| Q1 | Reference | Reference | ||
| Q2 | 1.47 (1.11–1.94) | 0.006 | 1.02 (0.77–1.34) | 0.92 |
| Q3 | 2.79 (2.17–3.59) | <0.001 | 1.64 (1.26–2.12) | <0.001 |
| Q4 | 3.68 (2.87–4.72) | <0.001 | 1.84 (1.42–2.38) | <0.001 |
| Q5 | 4.93 (3.87–6.29) | <0.0001 | 2.52 (1.96–3.24) | <0.001 |
| CKD progression | ||||
| Q1 | Reference | Reference | ||
| Q2 | 1.54 (1.23–1.93) | <0.001 | 1.05 (0.83–1.32) | 0.69 |
| Q3 | 1.96 (1.57–2.44) | <0.001 | 1.07 (0.85–1.34) | 0.57 |
| Q4 | 2.43 (1.96–3.02) | <0.001 | 1.06 (0.84–1.33) | 0.63 |
| Q5 | 3.06 (2.47–3.79) | <0.001 | 1.42 (1.14–1.78) | 0.002 |
| Hemoglobin decline | ||||
| Q1 | Reference | Reference | ||
| Q2 | 1.54 (1.25–1.90) | <0.001 | 1.30 (1.03–1.64) | 0.026 |
| Q3 | 2.06 (1.68–2.53) | <0.001 | 1.71 (1.30–2.26) | <0.001 |
| Q4 | 2.63 (2.16–3.22) | <0.001 | 2.19 (1.56–3.07) | <0.001 |
| Q5 | 3.25 (2.67–3.95) | <0.001 | 2.95 (1.99–4.38) | <0.001 |
CKD indicates chronic kidney disease; CVD, cardiovascular disease; HR, hazard ratio; IL‐6, interleukin‐6; and Q, quintile.
*
Adjusted for pooled cohort equation 10‐year CVD risk, education, urine albumin to creatinine ratio, estimated glomerular filtration rate, population stratification, and if necessary, for nonproportionality.