Table 3.
Subgroup Analysis by Hospital Unit (Surgery Versus Medicine) on the Proportion of Nonadministered Venous Thromboembolism Prophylaxis Medication Doses by Patient Bundle and Nurse Feedback Arms* , † , ‡
| Surgery | Medicine | |||||||
|---|---|---|---|---|---|---|---|---|
| Period | Patient education bundle | Nurse feedback | OR nurse feedback/patient bundle (95% CI) | P value* | Patient education bundle | Nurse feedback | OR nurse feedback/patient education bundle (95% CI) | P value* |
| Any nonadministered dose | ||||||||
| Preintervention, % (95% CI) | 6.3% (4.6%–8.6%) | 10.0% (7.4%–13.7%) | 1.68 (1.00–2.84) | 0.05 | 18.6% (14.5%–23.7%) | 18.9% (14.8%–24.0%) | 1.03 (0.68–1.55) | 0.89 |
| Postintervention (95% CI) | 3.3% (2.3%–4.7%) | 6.7% (4.6%–9.5%) | 2.11 (1.18–3.79) | 0.01 | 12.2% (9.2%–16.1%) | 15.2% (11.7%–19.9%) | 1.31 (0.84–2.06) | 0.24 |
| OR post/pre (95% CI) | 0.50 (0.39–0.65) | 0.63 (0.49–0.81) | 0.60 (0.49–0.74) | 0.77 (0.63–0.93) | ||||
| P value* | <0.001 | <0.001 | <0.001 | 0.01 | ||||
| Patient refused dose | ||||||||
| Preintervention (95% CI) | 2.7% (1.8%–4.2%) | 5.5% (3.6%–8.5%) | 2.13 (1.07–4.22) | 0.03 | 13.5% (9.7%–18.8%) | 13.8% (10.0%–19.1%) | 1.04 (0.62–1.75) | 0.89 |
| Postintervention (95% CI) | 1.0% (0.6%–1.8%) | 3.2% (1.9%–5.2%) | 3.12 (1.39–6.99) | 0.01 | 7.3% (5.0%–10.6%) | 11.2% (7.9%–15.9%) | 1.64 (0.93–2.89) | 0.09 |
| OR post/pre (95% CI) | 0.37 (0.23–0.59) | 0.55 (0.39–0.77) | 0.49 (0.38–0.64) | 0.79 (0.63–0.97) | ||||
| P value* | <0.001 | <0.001 | <0.001 | 0.02 | ||||
| Other reason for nonadministered dose (excluding patient refused) | ||||||||
| Preintervention (95% CI) | 3.0% (2.4%–3.9%) | 3.5% (2.7%–4.7%) | 1.18 (0.80–1.74) | 0.41 | 3.8% (3.0%–4.9%) | 4.0% (3.1%–5.1%) | 1.04 (0.72–1.49) | 0.84 |
| Postintervention (95% CI) | 1.9% (1.4%–2.6%) | 2.8% (1.9%–4.2%) | 1.50 (0.90–2.50) | 0.12 | 4.0% (3.0%–5.4%) | 3.2% (2.4%–4.2%) | 0.77 (0.51–1.17) | 0.22 |
| OR post/pre (95% CI) | 0.62 (0.46–0.83) | 0.79 (0.55–1.13) | 1.05 (0.78–1.43) | 0.78 (0.59–1.05) | ||||
| P value* | 0.002 | 0.19 | 0.74 | 0.10 | ||||
Patient education bundle refers to the Patient‐Centered Education Bundle. OR indicates odds ratio.
P values for the odds ratios were calculated using multiple outputation of the mixed‐effects logistics regression models.
Exponentiates 2‐way interactions were performed including pre vs post time period, and nurse feedback vs patient bundle units for surgery: OR, 1.26 (95% CI, 0.87–1.81); P=0.22 for any nonadministered dose; OR, 1.47 (95% CI, 0.83–2.60); P=0.19 for patient refused dose; OR, 1.27 (95% CI, 0.79–2.06); P=0.33 for other reasons for nonadministered doses (excluding patient refused). Medicine: OR, 1.28 (95% CI, 0.96–1.70); P=0.09 for any nonadministered dose; OR, 1.58 (95% CI, 1.13–2.20); P=0.01 for patient refused dose; OR, 0.74 (95% CI, 0.49–1.13); P=0.16 for other reasons for nonadministered doses (excluding patient refused).
Exponentiated 3‐way interactions were performed to calculate the ratio of ratios between ORs that examine whether the differences in ORs are different, including pre vs post time period, and nurse feedback vs patient bundle units, and surgery vs medicine with no significant differences observed: OR, 0.94 for any nonadministered dose; OR, 0.80 for patient refused dose; OR, 0.09 for other reasons for nonadministered doses (excluding patient refused).