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. 2022 Sep 8;11(18):e026670. doi: 10.1161/JAHA.122.026670

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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Scatter plot of the year 7 treadmill exercise duration in the CARDIA study vs the metabolomic fitness score. This plot included 1985 individuals at year 7 in the CARDIA study. R represents Spearman correlation. B, Spearman correlation matrix of cardiovascular risk factors and key metrics of fitness at year 7 in the CARDIA study. Each cell shows a Spearman correlation coefficient between each risk factor and treadmill exercise duration at year 7, the metabolomic fitness score, or cardiovascular health (CVH) score. Asterisks represent statistical significance at 0.05 level with Bonferroni type 1 error correction (P<0.0016). BMI indicates body mass index; BP, blood pressure; and HDL, high‐density lipoprotein.