Table 3.
Association of Metabolomic Fitness Score With Outcomes in CARDIA
| Outcome | No. of events/no. at risk | Standardized HR (95% CI) | P value | C index, base model | C index, base model+metabolomic fitness score | Δ C index (95% CI) |
|---|---|---|---|---|---|---|
| Mortality | ||||||
| Model 1: age‐, sex‐, race‐adjusted | 153/2300 | 0.56 (0.47 to 0.68) | <0.0001 | 0.641 | 0.706 | 0.064 (0.031 to 0.097) |
| Model 2: age‐, sex‐, race‐, CVH‐adjusted | 144/2205 | 0.60 (0.50 to 0.73) | <0.0001 | 0.698 | 0.727 | 0.030 (0.006 to 0.053) |
| Model 3: age‐, sex‐, race‐, risk factor‐adjusted | 153/2300 | 0.64 (0.52 to 0.77) | <0.0001 | 0.728 | 0.746 | 0.018 (0.001 to 0.036) |
| Cardiovascular disease | ||||||
| Model 1: age‐, sex‐, race‐adjusted | 116/2300 | 0.68 (0.55 to 0.84) | 0.0003 | 0.675 | 0.698 | 0.024 (0.000 to 0.048) |
| Model 2: age‐, sex‐, race‐, CVH‐adjusted | 107/2205 | 0.75 (0.59 to 0.95) | 0.016 | 0.739 | 0.746 | 0.008 (−0.008 to 0.023) |
| Model 3: age‐, sex‐, race‐, risk factor‐adjusted | 116/2300 | 0.77 (0.61 to 0.98) | 0.034 | 0.764 | 0.772 | 0.009 (−0.004 to 0.021) |
Clinical risk factors for model adjustment included: diabetes, body mass index, systolic blood pressure, total cholesterol, high‐density lipoprotein cholesterol, cigarettes per day at year 7, lifetime pack‐years smoking history up to year 7, CARDIA physical activity at year 7. CARDIA indicates Coronary Artery Risk Development in Young Adults study; CVH, cardiovascular health score; and HR, hazard ratio.