Table 2.
CMR Imaging Results Stratified by the Specific 2018 Lake Louis II Diagnosis of Myocarditis: Cardiac 18F‐FDG‐PET/CT Evidence of Myocardial Inflammatory Cell Infiltration
Patients | Myocarditis (CMR) | No myocarditis (CMR) | Inflammatory cell infiltration (cardiac PET) | No inflammatory cell infiltration (cardiac PET) | |
---|---|---|---|---|---|
No. | 26* | 9 | 16 | 7 | 16 |
LV ejection fraction, % | 61 [57–67] | 59 [56–62] | 64 [59–68] | 62 [60–63] | 60 [56–69] |
LV EDVi, mL/m2 | 65 [62–72] | 65 [60–73] | 66 [62–72] | 64 [56–75] | 66 [62–72] |
LV ESVi, mL/m2 | 25 [21–29] | 25 [21–32] | 22 [21–27] | 2 [20–32] | 26 [21–30] |
LV SVi, mL/m2 | 42 [34–48] | 38 [30–44] | 44 [38–49] | 38 [31–42] | 44 [36–50] |
RV ejection fraction, % | 56 [48–60] | 50 [47–58] | 58 [54–60] | 52 [48–56] | 59 [52–61] |
T1–maximum, ms | 1356 [1304–1412] | 1342 [1301–1403] | 1372 [1322–1414] | 1317 [1297–1405] | 1380 [1335–1424] |
T2–maximum, ms | 62 [57–68] | 68 [67–70] | 58 [56–62] | 66 [64–69] | 60 [56–63] |
ECV, maximum % | 31 [28–34] | 34 [31–36] | 29 [27–32] | 33 [31–35] | 30 [27–34] |
LGE, % | 9 (35) | 6 (67) | 2 (12) | 6 (86) | 3 (19) |
Subendocardial LGE, % | 2 (8) | 2 (22) | 0 (0) | 2 (29) | 0 (0) |
Mid‐wall, % | 8 (31) | 5 (56) | 2 (12) | 5 (71) | 3 (19) |
Myocarditis‐specific Lake Louis criteria, CMR | 9 (36) | 5 (71) | 3 (20) | ||
Myocardial inflammatory cell infiltration, PET | 7 (30) | 5 (63) | 2 (14) | ||
Pulmonary inflammation, percentage of lung | 17 [3–29] | 16 [2–30] | 17 [10–31] | 7 [2–20] | 22 [13–38] |
Pulmonary consolidation, percentage of lung | 12 [7–18] | 10 [8–16] | 13 [7–18] | 9 [8–12] | 16 [7–19] |
Data are provided as number, number (percentage), or median [interquartile range]. 18F‐FDG indicates 2‐deoxy‐2‐[fluorine‐18]fluoro‐D‐glucose; CMR, cardiac magnetic resonance; CT, computed tomography; ECV, extracellular volume; EDVi, indexed end‐diastolic volume; ESVi, indexed end‐systolic volume; LGE, late gadolinium enhancement; LV, left ventricle; PET, positron emission tomography; RV, right ventricle; SVi, systolic volume indexed; T1, longitudinal relaxation time; and T2, horizontal relaxation time.
Denominators differ for each modality because not all scans were performed/diagnostic on every patient.