Table 3.
Baseline Cardiac Parameters
| Parameters | Sacubitril/valsartan (n=26) | Conventional (n=23) | P value |
|---|---|---|---|
| Parameters of LV systolic function | |||
| LVEF, % | 31.31±5.53 | 35.73±4.21 | 0.015 |
| LVESV, mL | 95.75±33.30 | 80.11±23.04 | 0.356 |
| LVEDV, mL | 140.00±43.62 | 123.85±36.09 | 0.603 |
| LVIDs, mm | 47.19±6.88 | 44.93±7.24 | 0.603 |
| LVIDd, mm | 57.27±5.97 | 56.40±7.66 | 0.656 |
| Parameters of LV diastolic function | |||
| LAD, mm | 46.85±7.23 | 46.20±6.65 | 1 |
| LAVI, mL/m2 | 51.27±24.59 | 53.06±16.85 | 1 |
| MV E/A | 1.40±0.73 | 1.26±0.53 | 1 |
| E/Lat E' | 16.52±7.62 | 17.14±8.46 | 1 |
| E/Med E' | 26.07±15.59 | 23.55±9.15 | 1 |
| Peak TR Vel, cm/sec | 268.01±80.57 | 308.12±82.97 | 0.702 |
| Parameters of LV hypertrophy | |||
| IVSd, mm | 11.42±2.86 | 11.47±1.75 | 0.951 |
| LVPWd, mm | 10.73±1.97 | 11.52±1.54 | 0.384 |
| LV mass index, g/m2 | 157.28±43.65 | 167.88±48.86 | 0.852 |
| Other parameters | |||
| Aortic root, mm | 33.46±5.52 | 34.03±5.53 | 0.723 |
E/Lat E' indicates Doppler‐derived lateral E/e' ratio; E/Med E', Doppler‐derived medial E/e' ratio; IVSd, interventricular septum thickness in diastole; LAD, left atrial dimension; LAV, left atrial volume; LAVI, left atrial volume index; LV, left ventricular; LVEDV, left ventricular end‐diastolic volume; LVEF, left ventricular end‐systolic volume; LVESV, left ventricular end‐systolic volume; LVIDd, left ventricular internal diameter at end‐diastole; LVIDs, left ventricular internal diameter at end‐systole; LVPWd, left ventricular posterior wall thickness in diastole; MV E/A, tissue Doppler‐derived E/A ratio across the mitral valve; and Peak TR Vel, peak tricuspid regurgitation velocity.