Table 3.
Discrimination and Reclassification Statistics for 3‐Month Clinical Outcomes by Plasma YKL‐40 Among Patients With Acute Ischemic Stroke
| AUC | NRI | IDI | ||||
|---|---|---|---|---|---|---|
| Estimate (95% CI), % | P value | Estimate (95% CI), % | P value | Estimate (95% CI), % | P value | |
| Death or major disability (mRS score 3–6) | ||||||
| Conventional model | 0.747 (0.732–0.761) | Reference | Reference | |||
| Conventional model+YKL‐40 | 0.75 (0.735–0.764) | 0.099 | 15.61 (8.02–23.21) | <0.001 | 0.37 (0.12–0.62) | 0.004 |
| Major disability (mRS score 3–5) | ||||||
| Conventional model | 0.745 (0.73–0.76) | Reference | Reference | |||
| Conventional model+YKL‐40 | 0.747 (0.732–0.762) | 0.158 | 11.35 (3.44–19.26) | 0.005 | 0.17 (−0.01–0.34) | 0.06 |
| Death | ||||||
| Conventional model | 0.732 (0.717–0.747) | Reference | Reference | |||
| Conventional model+YKL‐40 | 0.758 (0.743–0.772) | 0.049 | 42.75 (22.09–63.42) | <0.001 | 1.37 (0.54–2.2) | 0.001 |
Conventional model included age, sex, admission National Institutes of Health Stroke Scale score, antihypertensive treatment, time from onset to hospitalization, current smoking, alcohol consumption, body mass index, dyslipidemia, fasting plasma glucose, history of hypertension, history of diabetes, family history of stroke, systolic blood pressure at baseline, and ischemic stroke subtypes. AUC indicates area under the receiver operating characteristic curve; IDI, integrated discrimination index; mRS, modified Rankin Scale; NRI, net reclassification improvement; and YKL‐40, human cartilage glycoprotein‐39.