Table 2. Top 10 novel protein-coding genes significant by colocalization (RCP ≥0.5) and TWAS, sorted by TWAS p value.
Gene | Tissue with greatest RCP | Max. RCP | TWAS p value (Bonferroni) | # GTEx tissues with RCP ≥0.5 |
---|---|---|---|---|
SPTBN1 | Cells_Cultured_fibroblasts | 0.9469 | <5 × 10−324 | 2 |
PPP6R3 | Thyroid | 0.5291 | 5.7 × 10−93 | 1 |
BARX1 | Colon_Transverse | 0.7764 | 6.36 × 10−63 | 1 |
MEOX2 | Brain_Nucleus_accumbens_basal_ganglia | 0.6286 | 3.21 × 10−53 | 3 |
RERE | Adipose_Subcutaneous | 0.6431 | 6.95 × 10−46 | 4 |
SIPA1 | Nerve_Tibial | 0.9981 | 4.26 × 10−41 | 1 |
CAPZB | Testis | 0.6716 | 3.64 × 10−33 | 1 |
B4GALNT3 | Artery_Aorta | 0.9241 | 2.67 × 10−33 | 4 |
TRPC4AP | Breast_Mammary_Tissue | 0.5577 | 8.62 × 10−31 | 3 |
AXL | Minor_Salivary_Gland | 0.6205 | 9.74 × 10−31 | 3 |