Appendix 3—figure 14. The Lande case: the long-term relative contribution to the change in mean phenotype coming from different initial MAFs is approximately constant.

The simulation results were generated using the all alleles simulation, as described in Choice of simulation parameters. The results for a given case were binned by initial minor allele frequency (with boundaries between the bins marked by the light grey vertical lines). The total contributions of alleles in frequency bin ${\displaystyle (x_1,x_2]}$ is divided by the total mutational input per generation times the size of the bin, $2NU(x_2-x_1)$ . The analytic predictions were based on the linear Lande approximation (Equation A3-63 or Equation 19 in the main text).