Appendix 3—figure 17. The non-Lande case: The long-term relative contribution to the change in mean phenotype coming from different initial MAFs is approximately constant, with low initial MAF alleles contributing slightly more than high initial MAF alleles.

The slight excess in the contribution of alleles with low initial MAF is especially pronounced when the shift is large and the polygenicity is low. The simulation results were generated using the all alleles simulation, as described in Section 2.1. We calculate the relative contribution of alleles in each MAF bin ${\displaystyle (x_1,x_2)}$ (between the gray gridlines) by dividing the contribution of fixations in the bin by the total mutational input per generation times the size of the bin, $2NU(x_2-x_1)$ . The analytic predictions were based on the linear non-Lande approximation (Equation A3-71 or Equation 24 in the main text).