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. 2022 Nov 24;226:1116–1140. doi: 10.1016/j.ijbiomac.2022.11.227

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Fig. 12 — A) Graphical representation of tunnels and cavities (shown in red) around Pro₆₈₁ and Arg_681, B) Representation of Furin target site in native (left panel) and mutant (right panel) Spikes. As shown in the right panel, the region near the Furin cleavage site is more open in the mutant structure than in the wild-type structure.