Table 2.
KEGG enrichment analysis of BHD-BM module.
| GO | Description | Count | Log P | Hits |
|---|---|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | 35 | -38.739 | AKT1, CCND1, BCL2, BCL2L1, CASP9, CDK2, CDK4, CDKN1A, CHUK, COL1A1, EGF, EGFR, ERBB2, ERBB3, GSK3B, HSP90AA1, IGF2, IKBKB, IL2, IL4, IL6, MCL1, MDM2, MET, MYC, NOS3, PIK3CG, MAPK1, MAPK3, PTEN, RAF1, RELA, SPP1, TP53, and VEGFA |
| hsa05205 | Proteoglycans in cancer | 29 | -36.389 | AKT1, CCND1, CASP3, CAV1, CD44, CDKN1A, COL1A1, MAPK14, CTNNB1, EGFR, ERBB2, ERBB3, ESR1, HIF1A, IGF2, MDM2, MET, MMP2, MMP9, MYC, PLAU, PRKACA, MAPK1, MAPK3, RAF1, TNF, TP53, VEGFA, and HPSE |
| hsa05215 | Prostate cancer | 28 | -44.178 | AKT1, AR, CCND1, BCL2, CASP9, CDK2, CDKN1A, CHUK, CTNNB1, E2F1, EGF, EGFR, ERBB2, GSK3B, HSP90AA1, IKBKB, MDM2, MMP3, MMP9, NFKBIA, PLAU, MAPK1, MAPK3, PTEN, RAF1, RB1, RELA, and TP53 |
| hsa04010 | MAPK signaling pathway | 28 | -30.404 | AKT1, CASP3, CHUK, MAPK14, EGF, EGFR, ERBB2, ERBB3, FOS, HSPB1, IGF2, IKBKB, IL1A, IL1B, JUN, MET, MYC, PPP3CA, PRKACA, MAPK1, MAPK3, MAPK8, RAF1, RASA1, RELA, TNF, TP53, and VEGFA |
| hsa04657 | IL-17 signaling pathway | 25 | -38.472 | CASP3, CASP8, CHUK, MAPK14, FOS, GSK3B, HSP90AA1, IFNG, IKBKB, IL1B, IL4, IL6, CXCL8, JUN, MMP1, MMP3, MMP9, NFKBIA, MAPK1, MAPK3, MAPK8, PTGS2, RELA, CCL2, and TNF |
| hsa04218 | Cellular senescence | 25 | -32.725 | AKT1, CCND1, CCNA2, CDK1, CDK2, CDK4, CDKN1A, MAPK14, E2F1, IGFBP3, IL1A, IL6, CXCL8, MDM2, MYC, SERPINE1, PPP3CA, MAPK1, MAPK3, PTEN, RAF1, RB1, RELA, TP53, and CHEK2 |
| hsa05206 | MicroRNAs in cancer | 25 | -25.295 | CCND1, BCL2, CASP3, CD44, CDKN1A, E2F1, EGFR, ERBB2, ERBB3, HMOX1, IKBKB, MCL1, MDM2, MET, MMP9, ABCC1, MYC, PLAU, MAPK1, MAPK3, PTEN, PTGS2, RAF1, TP53, and VEGFA |
| hsa04668 | TNF signaling pathway | 23 | -32.674 | AKT1, CASP3, CASP8, CHUK, MAPK14, FOS, ICAM1, IKBKB, IL1B, IL6, JUN, MMP3, MMP9, NFKBIA, MAPK1, MAPK3, MAPK8, PTGS2, RELA, CCL2, SELE, TNF, and VCAM1 |
| hsa05224 | Breast cancer | 23 | -29.847 | AKT1, BAX, CCND1, CDK4, CDKN1A, CTNNB1, E2F1, EGF, EGFR, ERBB2, ESR1, ESR2, FOS, GSK3B, JUN, MYC, PGR, MAPK1, MAPK3, PTEN, RAF1, RB1, and TP53 |
| hsa04210 | Apoptosis | 22 | -28.889 | AKT1, BIRC5, BAX, BCL2, BCL2L1, CASP3, CASP8, CASP9, CHUK, CTSD, FOS, IKBKB, JUN, MCL1, NFKBIA, MAPK1, MAPK3, MAPK8, RAF1, RELA, TNF, and TP53 |
| hsa04625 | C-Type lectin receptor signaling pathway | 21 | -29.677 | AKT1, CASP8, CHUK, MAPK14, IKBKB, IL1B, IL2, IL6, IL10, JUN, MDM2, NFKBIA, PPP3CA, MAPK1, MAPK3, MAPK8, PTGS2, RAF1, RELA, STAT1, and TNF |
| hsa04660 | T cell receptor signaling pathway | 21 | -29.677 | AKT1, CD40LG, CDK4, CHUK, MAPK14, FOS, GSK3B, IFNG, IKBKB, IL2, IL4, IL10, JUN, NFKBIA, PPP3CA, MAPK1, MAPK3, MAPK8, RAF1, RELA, and TNF |
| hsa05222 | Small-cell lung cancer | 21 | -30.829 | AKT1, BAX, CCND1, BCL2, BCL2L1, CASP3, CASP9, CDK2, CDK4, CDKN1A, CHUK, E2F1, IKBKB, MYC, NFKBIA, NOS2, PTEN, PTGS2, RB1, RELA, and TP53 |
| hsa05208 | Chemical carcinogenesis—reactive oxygen species | 20 | -21.114 | AKT1, CHUK, MAPK14, EGF, EGFR, FOS, HIF1A, HMOX1, IKBKB, JUN, MET, NFKBIA, MAPK1, MAPK3, MAPK8, PTEN, RAF1, RELA, SOD1, and VEGFA |
| hsa04659 | Th17 cell differentiation | 19 | -25.608 | CHUK, MAPK14, FOS, HIF1A, HSP90AA1, IFNG, IKBKB, IL1B, IL2, IL4, IL6, JUN, NFKBIA, PPP3CA, MAPK1, MAPK3, MAPK8, RELA, and STAT1 |
| hsa04621 | NOD-like receptor signaling pathway | 19 | -21.190 | BCL2, BCL2L1, CASP8, CHUK, MAPK14, HSP90AA1, IKBKB, IL1B, IL6, CXCL8, JUN, NFKBIA, MAPK1, MAPK3, MAPK8, RELA, CCL2, STAT1, and TNF |
| hsa04620 | Toll-like receptor signaling pathway | 18 | -24.128 | AKT1, CASP8, CHUK, MAPK14, FOS, IKBKB, IL1B, IL6, CXCL8, JUN, NFKBIA, MAPK1, MAPK3, MAPK8, RELA, SPP1, STAT1, and TNF |
| hsa04380 | Osteoclast differentiation | 18 | -22.496 | AKT1, CHUK, MAPK14, FOS, IFNG, IKBKB, IL1A, IL1B, JUN, NFKBIA, PPARG, PPP3CA, MAPK1, MAPK3, MAPK8, RELA, STAT1, and TNF |
| hsa05202 | Transcriptional misregulation in cancer | 18 | -19.335 | BAX, BCL2L1, RUNX2, CCNA2, CDKN1A, IGFBP3, IL6, CXCL8, MDM2, MET, MMP3, MMP9, MPO, MYC, PLAU, PPARG, RELA, and TP53 |
| hsa04115 | p53 signaling pathway | 17 | -25.120 | BAX, CCND1, BCL2, BCL2L1, CASP3, CASP8, CASP9, CDK1, CDK2, CDK4, CDKN1A, IGFBP3, MDM2, SERPINE1, PTEN, TP53, and CHEK2 |