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. 2022 Nov 16;2022:8077281. doi: 10.1155/2022/8077281

Figure 1.

Figure 1

Inhibition of T-cell proliferation by NDGs and the effect of catalase, nor-NOHA, GAL, and CD11b on proliferation restoration. (a) Inhibition of T-cell proliferation by nonactivated NDGs (n = 15). Neutrophils suppress T-cell proliferation (p < 0.001), and addition of ROS inhibitor catalase protects T-cell proliferation (p = 0.048). The arginase inhibitor nor-NOHA did not have a protective effect and neither did TGF-β inhibitor GAL. Addition of anti-CD11b antibody protected T-cell proliferation (p = 0.0040). (b) Inhibition of T-cell proliferation by fMLF activated NDGs (n = 9). fMLF activated NDGs inhibit T-cell proliferation (p = 0.0039), and the proliferation was improved by catalase (p = 0.016) and anti-CD11b (p = 0.031). nor-NOHA and GAL did not improve proliferation. Graphs indicate median with 95% CI, and statistical significance was tested using Wilcoxon matched pairs signed rank test.