Figure 6.

Topological analysis identifies hub and driver genera in microbiota networks

A. MCC scores from the whole network and top 10 hub genera in the SparCC networks for the four age groups and all samples. B. Venn plot showing the overlap of hub genera among the four age groups. Genera are colored blue if negatively associated with age, and red if positively associated with age. C. NetShift common sub-networks based on the SparCC networks with highlighted driver genera. Node sizes are in proportion to their NESH scores, and the nodes representing the potential drivers are highlighted in red. Edges are colored in red if present only in case, in green if present only in control, and in blue if present in both. Node names without underlines denote age-associated genera. MCC, maximal clique centrality; NESH, neighbor shift.