Table 2.

Typical drug hypersensitivity reaction-related HLA alleles (37–39).

Drug	HLA allele	ADHRs
Abacavir (40, 41)	HLA-B*5701	Rash, gastrointestinal tract and respiratory symptoms
Allopurinol (42, 43)/Oxypurinol (metabolite of allopurinol) (44, 45)	HLA-B*5801	Maculopapular eruption, severe cutaneous adverse reactions, SJS, TEN, drug reaction with eosinophilia and systemic symptoms (DRESS)
Carbamazepine (46, 47)	HLA-B*1502 HLA-A*1301	MPE, DRESS, SJS, TEN
Methazolamide (48, 49)	HLA-B*5901 HLA-B*5502	SJS, TEN
Dapsone (50, 51)	HLA-A*1301	Eosinophilia and systemic symptoms
Oxcarbazepine (52, 53)	HLA-B*1502	SJS, TEN
Penicillin (54, 55)	HLA-B*5501 HLA-DR	DRESS, MPE, SJS, TEN