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. 2022 Nov 14;6(1):e202201429. doi: 10.26508/lsa.202201429

Figure 6. SMA-linked SMN mutants prevent droplet formation.

Figure 6.

(A) Recombinant SMN and SMNG275S were labelled with Cy3 and Cy5, respectively, mixed, and allowed to form droplets. Droplets were visualized as described in Fig 5. (B) SMNG275S formed aggregates. (C) SMNE134K formed aggregates that overlap with fluorescein-labelled RNA. All images were captured with a 40X objective.