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. 2022 Nov 10;13:1015283. doi: 10.3389/fimmu.2022.1015283

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Copyright © 2022 Zhou, Shayan, Sun, Huang, Chen, Wang, Qu, Wu, Zhang, Liu, Zhang, Luo, Shi, Liu, Liang, Li, Wang and Yi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Composition of heterogeneous infiltrating immune cell subpopulations in Group 1 and Group 2. (A) Relative distribution of all analyzed cell phenotypes in NPC sample tissues. (B-D) Relative distribution analysis of different T cell subtypes between two groups, firstly by separating the total cell number into other, CK+ cells or CD3+ T cells (including all T cell subtypes) (B); then focusing on CD3+ T cells and dividing them into CD4+ T (CD3+CD4+), CD8+ (CD3+CD8+) and other (CD3+CD4-CD8-) cells (C); and finally focusing on CD3+CD4+ T cells and dividing them into Foxp3+ and Foxp3- T cells (D). (E-H) Pairwise comparisons of the density of TIL subpopulations between the two groups for TILs (E), CTLs (F), Teffs (G) and Tregs (H). (I-L) Pairwise comparisons of PDL1 positive TIL subpopulations between the two groups. *p < 0.05, **p < 0.01, ns, not significant.