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. 2022 Nov 10;13:1015283. doi: 10.3389/fimmu.2022.1015283

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Copyright © 2022 Zhou, Shayan, Sun, Huang, Chen, Wang, Qu, Wu, Zhang, Liu, Zhang, Luo, Shi, Liu, Liang, Li, Wang and Yi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial distribution of heterogeneous infiltrating immune cell subpopulations. (A) Pairwise comparison of the infiltration differences for TILs, CTLs, Teffs, Tregs and PDL1+ Tregs in the whole population between inner and stroma area. (B) Pairwise comparison of the infiltration differences for TILs, CTLs, Teffs, Tregs and PDL1+ Tregs within inner area between two groups. (C) Pairwise comparison of the infiltration differences for TILs, CTLs, Teffs, Tregs and PDL1+ Tregs in stroma area between two groups. (D) Schematic model for different scenarios of infiltration with the same number of immune cells locating within a 20 um radius of the tumor cell, reflecting distinct engagement level of immune cells. (E) Pairwise comparisons of the Gcross-AUC values for G_TC : _CTL, G_TC : _Treg, G_TC : _Teff, G_TC : _PDL1+Treg, G_CTL : _Treg and G_CTL : _PDL1+Treg between two groups. (F-H) Pairwise comparisons of the G-cross values at 20 um (F), 30 um (G) and 50 um (H) radii for G_TC : _CTL, G_TC : _Treg, G_TC : _Teff, G_TC : _PDL1+Treg, G_CTL : _Treg and G_CTL : _PDL1+Treg between two groups. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant.