. 2022 Nov 10;13:1045206. doi: 10.3389/fmicb.2022.1045206

Table 2.

Overview of the recommendations for antimicrobial treatment of CRAB infections in Arab countries in the Middle East, Italy, and China.

Arab countries of the Middle East	Italy	China
Bacteraemia and nosocomial pneumonia: stable patients: Colistin^a or polymyxin B monotherapy critically ill patients: Colistin^a or polymyxin B in combination with one of the following: Aminoglycoside^b Ampicillin/sulbactam Carbapenem (high-dose, extended infusion) Fosfomycin Minocycline Rifampicin Tigecycline (high-dose)	cUTI and cSSTI Monotherapy with one of the following: Aminoglycoside Ampicillin/sulbactam Carbapenem (high-dose, extended infusion) Colistin Doxycycline^c Fosfomycin^d Tigecycline^c Trimethoprim-sulfamethoxazole	Strongly recommend a consultation by specialists; Rigorous monitoring of renal function is strongly recommend when colistin is administered; Further studies are necessary to estimate the use of cefiderocol.	First choice according to drug sensitivity results: Compound preparation containing sulbactam Aminoglycoside Fluoroquinolone Minocycline SMZ-TMP Secondary choice according to drug sensitivity results: Tigecycline Polymyxin Other β Lactamase inhibitor compound preparations

Arab countries of the Middle East

Italy

China

Bacteraemia and nosocomial pneumonia:
stable patients:

Colistin^a or polymyxin B monotherapy

critically ill patients:

Colistin^a or polymyxin B in combination with one of the following:
Aminoglycoside^b
Ampicillin/sulbactam
Carbapenem (high-dose, extended infusion)
Fosfomycin
Minocycline
Rifampicin
Tigecycline (high-dose)

cUTI and cSSTI
Monotherapy with one of the following:

Aminoglycoside
Ampicillin/sulbactam
Carbapenem (high-dose, extended infusion)
Colistin
Doxycycline^c
Fosfomycin^d
Tigecycline^c
Trimethoprim-sulfamethoxazole

Strongly recommend a consultation by specialists;
Rigorous monitoring of renal function is strongly recommend when colistin is administered;
Further studies are necessary to estimate the use of cefiderocol.

First choice according to drug sensitivity results:

Compound preparation containing sulbactam
Aminoglycoside
Fluoroquinolone
Minocycline
SMZ-TMP

Secondary choice according to drug sensitivity results:

Tigecycline
Polymyxin
Other β Lactamase inhibitor compound preparations

cUTI, complicated urinary tract infection; cSSTI, complicated skin and soft tissue infection; SMZ-TMP, sulfamethoxazole-trimethoprim. ^a intravenous and inhaled (nebulized) for patients with pneumonia. ^b for bacteraemia only. ^c for cSSTI only. ^d for cUTI only.