Figure 6:

Individual linear estimates of change in Clinical Dementia Rating–Sum of Boxes over time in symptomatic mutation carriers with and without Alzheimer disease neurological examination findings. Description: Individual decline in Clinical Dementia Rating – Sum of Boxes over time was significantly more pronounced in symptomatic mutation carriers with Alzheimer disease neurological examination findings compared to those without. The individual linear changes in Clinical Dementia Rating–Sum of Boxes were predicted by a linear mixed effects model based on longitudinal data, i.e. data from symptomatic mutation carriers with at least the baseline visit and one follow-up visit. Abbreviations: MC=mutations carriers; CDR-SB=Clinical Dementia Rating–Sum of Boxes; AD-NEF=Alzheimer disease neurological examination findings.