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. 2022 Nov 10;10:1025155. doi: 10.3389/fbioe.2022.1025155

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Copyright © 2022 Wang, Guo, Liang, Li, Song, Luo, Ai, Li and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic efficacy of Cur–AceKGM NPs in mice with DSS-induced colitis. (A) Body weight percentage variation during the treatment with physiological saline, physical mixture of curcumin and AceKGM nanoparticles (Cur&NPs), dexamethasone, and Cur–AceKGM NPs; **p < 0.01 and ***p < 0.001 versus the control group. (B) Disease activity index score. (C) MPO activity determination of the colon tissue. (D) Statistical analysis of colon length in different treatment groups, (E) colon tissue TNF-α amounts, measured by ELISA assays. (F) Gross view of the colon. All the experiments were performed in triplicate, and data are shown as mean ± SD. ***p < 0.001 and **p < 0.01.