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. 2022 Nov 23;13:7204. doi: 10.1038/s41467-022-34784-7

Fig. 6. In vivo base editing of pathogenic sites in mtDNA.

Fig. 6

a Mitochondrial DNA base editing efficiencies installing m.7743G>A of tissue samples from mice treated with buffer, dAAV-Mt-tk, or AAV-Mt-tk. b Mitochondrial DNA base editing efficiencies of tissue samples from AAV-Mt-tk-treated mice. c Off-target editing efficiencies within representative mitochondrial off-target amplicon OT8 of tissue samples from mice treated with buffer, dAAV-Mt-tk, or AAV-Mt-tk. d Mitochondrial DNA base editing efficiencies installing m.3177G>A of tissue samples from mice treated with buffer or AAV-Nd1. e Mitochondrial DNA base editing efficiencies of tissue samples from AAV-Nd1-treated mice. f Off-target editing efficiencies within representative mitochondrial off-target amplicon OT7 of tissue samples from mice treated with buffer, or AAV-Nd1. For (a and b), values and errors reflect the mean ± s.d. of n = 4, 4 and 7 for mice treated with buffer, AAV-Mt-tk, or dAAV-Mt-tk, respectively. For (c), values reflect the mean of n = 4, 4 and 7 for mice treated with buffer, AAV-Mt-tk, or dAAV-Mt-tk, respectively. For (d and e), values and errors reflect the mean ± s.d. of n = 4 and 7 for mice treated with buffer or AAV-Nd1, respectively. For (f), values reflect the mean of n = 4 and 7 for mice treated with buffer or AAV-Nd1, respectively. Source data are provided as a Source Data file.