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. 2022 Nov 22;8:124. doi: 10.1038/s41523-022-00491-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The underlying histological patterns of TS-score characterizing at the patch-level (a, b) and WSI-level (c–e). a Tiles with extremal TS-scores associated with pCR and non-pCR were extracted to be reviewed by a pathologist. Scale bars, 233 μm. b The distribution of tiles with different stromal type between extremal high TS-score and low TS-score group. c Examples of different stromal type: collagen-dominant stromal (C type), fibroblast-dominant stroma (F type), lymphocyte-dominant stroma (L type). Scale bars, 100 μm. d The distributions of TS-scores among the three stromal type evaluated at WSI-level. e The different percentage of the three stromal type between pCR and non-pCR group.