Table 2.
Univariate and multivariate analysis of TS-score correlating with pCR in primary cohort.
| Factors | Univariate analysis | Multivariate analysisa | Multivariate analysisb | |||
|---|---|---|---|---|---|---|
| OR(95% CI) | P | OR(95% CI) | P | OR(95% CI) | P | |
| TS-score | – | <0.001 | – | – | – | <0.001 |
| Subtypes | – | <0.001 | – | <0.001 | – | <0.001 |
| HR+/HER2− | 1 | – | 1 | – | 1 | – |
| HER2+ | 9.28 (5.91–14.6) | <0.001 | 7.47 (4.66–12.0) | <0.001 | 7.73 (4.76–12.5) | <0.001 |
| TNBC | 5.21 (3.04–8.93) | <0.001 | 3.73 (2.10–6.62) | <0.001 | 3.33 (1.86–5.97) | <0.001 |
| sTILs | – | <0.001 | – | <0.001 | – | 0.766 |
| Low | 1 | – | 1 | – | 1 | – |
| Moderate | 7.58 (4.00–14.4) | <0.001 | 1.76 (1.16–2.69) | 0.009 | 1.03 (0.64–1.66) | 0.905 |
| High | 2.78 (1.47–5.25) | 0.002 | 4.58 (2.20–9.54) | <0.001 | 1.36 (0.57–3.27) | 0.490 |
| cT | 0.61 (0.43–0.86) | 0.005 | 0.73 (0.49–1.10) | 0.130 | 0.77 (0.51–1.16) | 0.204 |
| Ki67 | 2.63 (1.40–4.94) | 0.003 | 1.40 (0.69–2.81) | 0.348 | 1.19 (0.58–2.46) | 0.636 |
| NG | 2.59 (1.80–3.70) | <0.001 | 1.37 (0.91–2.07) | 0.137 | 1.21 (0.79–1.85) | 0.372 |
Multivariate analysis arefers to the multivariate analysis excluding TS-score; Multivariate analysis brefers to the multivariate analysis including the TS-score.
TS-score tumor-stroma score, HR hormone receptor, HER2 human epidermal growth factor receptor 2, sTILs stromal tumor-infiltrating lymphocytes, NG nuclear grade.