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. 2022 Nov 23;13:7200. doi: 10.1038/s41467-022-34679-7

Fig. 3. Impaired spatial learning and memory in C57BL/6 PKCα M489V/M489V mice in the Barnes maze test.

Fig. 3

a Schematic of the Barnes maze test. Created with Biorender.com. b–d Percent time spent in the target quadrant (filled bars) versus the average of the other quadrants (open bars) in the probe test in separate groups of 3 (b), 6 (c), and 12 (d) months old mice. Group sizes: 3-month (WT: 4 males, 8 females, M489V littermates: 6 males, 6 females), 6-month (WT: 8 males, 8 females, M489V littermates: 8 males, 8 females), 12 month (WT: 7 males, 12 females, M489V littermates: 12 males, 11 females). Error bars show standard error of the mean. No statistically significant sex differences were found. ANOVA was used for statistical analysis, followed by post hoc two-tailed Student’s t test to determine the p values. Source data are provided in the Source Data file.