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. 2022 Nov 22;13:7171. doi: 10.1038/s41467-022-34917-y

Fig. 4. Luciferase activity in hiPSC-derived cardiomyocyte cells (hiPSC-CMs) transfected with empty vector (EV), major allele (G)-, or risk allele (A)-constructs.

Fig. 4

Schematic of the luciferase construct to test the enhancer activity of rs28714259 locus (Top). Luciferase activity in transfected cells treated with vehicle or dexamethasone (bottom). Three independent experiments were performed with three technical repeats for each construct transfection (n = 9). Data are mean ± sd. Two-tailed unpaired t-tests were used to estimate significance. P-values are indicated in the figure. Source data are provided as a Source Data file.