Fig. 6. rs28714259 risk (A) allele dysregulates genes following dexamethasone/doxorubicin combination treatment and contributes to an attenuated hypertrophy signaling.

Top genes identified by IPA (in red or green blocks with bold black frame) are depicted in the context of canonical pathways. Red: pro-hypertrophic genes AND upregulated under dexamethasone/doxorubicin combination by rs28714259 major (G) allele. Green: anti-hypertrophic genes AND down-regulated under dexamethasone/doxorubicin combination by rs28714259 major (G) allele. Small arrows placed on the right side of identified genes represent the effect of rs28714259 risk (A) allele, which consistently opposes the effect of major (G) allele. Only top genes (P-value <= 2.81 × 10−³) in the cardiac hypertrophy signaling pathway identified by Ingenuity Pathway Analysis are shown for simplicity. A complete list of the 31 genes identified is included in Supplementary Table 6.