Fig. 1. The distribution of differentially methylated CpGs.
a QQ-plot of the p-values from the EWAS model. The genomic control inflation rate of the EWAS model is 1.1, indicating a modest inflation. The x-axis shows the expected –log10 (p-value), whereas the y-axis indicates the observed –log10 (p-value). b Manhattan plot of the EWAS results between DLB and Control samples. The red line indicates the genome-wide significance threshold (p-value = 9e-8) and blue line represents a q-value of 5 % adjusting for multiple comparisons. The top DMCs per chromosome are annotated.
