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Genetic organization of DNA flanking Tn4351 target sequence in P. gingivalis MSM-3 genome. Tn4351 contains a tetracycline resistance gene (Tcr) and an erythromycin-clindamycin resistance gene (Emr) flanked by direct repeat insertion sequence IS4351. The Tn4351 insertion was located 60 bp upstream from an IS1126 element (designated IS1126Tn). Arrows in ORF1, IS1126Tn, and ORF2 indicate the direction of transcription. H, HindIII.
