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. 2022 Nov 10;12:1042945. doi: 10.3389/fcimb.2022.1042945

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Copyright © 2022 He, Wang, Ke, Zhang, Ning, Zhang, Yang, Shi, Fang, Ming, Li, Zhang, Dong, Liu, Zhou, Xia and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the RPM detected by mNGS of both cfDNA and wcDNA. (A), All microbes detected by mNGS. (B), Bacteria detected by mNGS. (C), Fungi detected by mNGS. (D), Viruses detected by mNGS. The number of microbes and base-2 logarithm of reads per million (RPM) detected by mNGS of cfDNA divided by that detected by mNGS of wcDNA for the same microbes were used to draw scatter plot, and the dots of >0 represented that the numbers of RPM detected by mNGS of cfDNA was higher than that detected by mNGS of wcDNA for the microbes. The microbes only detected by mNGS of cfDNA or wcDNA were summarized in Table 3 .