Table 1.

Detailed information of miRNAs targeting TME to regulate ovarian cancer.

miRNA	Target genes	Related hallmark	Expression	reference
miR-204-5p	THBS1	Tumor angiogenesis	Promote	(10, 39)
miR-484 miR-642 miR-217	VEGFB/VEGFR2	Tumor angiogenesis	Promote	(40)
miR-21 miR-27a	HIF1- α/VEGF	Tumor angiogenesis	Promote	(41, 42)
miR-141-3p	JAK/STAT3/VEGFR2	Tumor angiogenesis	Promote	(43)
miR-205	PTEN/AKT	Tumor angiogenesis	Promote	(44)
miR-145	HIF1- α/VEGF	Tumor angiogenesis	Inhibit	(45)
miR-497	PI3K/AKT	Tumor angiogenesis	Inhibit	(46)
miR-195-5p	GSK3β/β-catenin	Tumor angiogenesis	Inhibit	(47)
miR-181	RTKN2	Tumor angiogenesis	Inhibit	(48)
miR-29b	MMP-2	Tumor-associated fibroblast	Inhibit	(49)
miR-214	CCL5	Tumor-associated fibroblast	Inhibit	(50)
miR-98-5p	CDKN1A	Tumor-associated fibroblast	Inhibit	(51)
miR-124	SPHK1	Tumor-associated fibroblast	Inhibit	(52)
miR-29a-3p miR-21-5p	STAT3	Immune-suppressive	Inhibit	(53)
miR-125b	ID8-VEGF	Immune-suppressive	Inhibit	(54)
miR-222-3P	SOCS3/STAT3	Immune-suppressive	Promote	(55)
miR-223	PTEN-PI3K/AKT	Immune-suppressive	Promote	(56)
miR-7	EGFR/AKT/ERK1/2	Immune-suppressive	Inhibit	(57)
miR-221-3p	CDKN1B	Immune-suppressive	Promote	(58)
miR-1246	Cav1/p-gp/M2	Immune-suppressive	Inhibit	(59)
miR-200b	KLF6	Immune-suppressive	Inhibit	(60)
miR-424(322)	PD-L1/PD-1 CD80/CTLA-4	Immune-suppressive	Promote	(61)
miR-142	Sirt1	Immune activity	Promote	(62)
miR-20a	MICA/B	Immune activity	Inhibit	(63)
miR-155	Ago2	Immune activity	Inhibit	(64)
miR-22 miR-503	PI3K/AKT/MAPK Bcl2	Immune activity Immune activity	Inhibit Inhibit	(65) (65)