Table 2.
Different physicochemical properties of receptor-binding domain of different SARS-CoV-2 variants
| Variant name | Number of domain residues | Mol. wt | Iso-electric point | SASA | Solubility | Surface charge | Stability (Tm) (°C) |
|---|---|---|---|---|---|---|---|
| wt-RBD | 195 | 21,855.6 | 8.0 | 10,018.9 | 0.2 | 0 | 62 |
| Alpha | 195 | 21,903.7 | 8.6 | 10,155.3 | 0.2 | + 2 | 63 |
| Delta | 195 | 21,925.7 | 8.6 | 10,207.8 | 0.2 | + 1 | 62 |
| Omicron | 195 | 22,145.1 | 8.7 | 10,379.5 | 0.2 | + 1 | 65 |
Surface charge was calculated based on difference of surface exposed charge (ASP + GLU) to (LYS + ARG) residues