Table 4.

Risk of bias assessment of the RCT research

	Domain 1			Domain 2			Domain 3			Domain 4		Domain 5				Overall Risk of Bias
Study ID	1.1 Random allocation?	1.2 Allocation sequence concealed?	1.3 ROB	2.1. Participants blinded to the intervention?	2.2. Carers/interventionists blinded to the intervention?	2.3 ROB	3.Outcome data available for all participants?	3.2 Bias due to Missing outcome?	3.3 ROB	4.1 Inappropriate method to measure the outcome?	4.3 ROB	5.1 Pre-specified analysis plan?	5.2 Selected reported outcome?	5.3 A priori protocol?	5.4 ROB	Summary ROB
S01	Yes	Yes	Low	NI	PY	SC	Yes	No	Low	No	Low	Yes	No	No	Low	SC
S02	No	PY	SC	NI	NI	SC	No	NI	SC	No	Low	No	PN	N	High	High
S03	Yes	PY	Low	PN	PY	SC	Yes	PN	Low	No	Low	No	No	PY	SC	SC
S04	Yes	PN	Low	NI	NI	Low	Yes	No	Low	No	Low	PY	N	N	SC	SC
S05	PY	PN	Low	PN	PY	Low	Yes	PN	Low	No	Low	PY	PN	PY	Low	Low
S06	Yes	PY	Low	No	PN	Low	Yes	PN	Low	No	Low	PY	PN	Yes	Low	Low
S07	Yes	PY	Low	No	No	Low	PY	Y	SC	No	Low	PN	No	No	SC	SC
S08	Yes	Yes	Low	PY	PN	SC	PY	PN	Low	PY	Low	PY	PN	PN	SC	SC