Table 8.
ROC curve analysis for NEAT1, HOTAIR, and GAS5 in the CVS-HTN, CVS-NHTN patients, and the healthy control groups.
| CVS-HTN patients vs. control | ||||||
|---|---|---|---|---|---|---|
| LncRNA | AUC 95% CI |
P-value | Cut-off point | Sensitivity (%) | Specificity (%) | Total accuracy |
| NEAT1 | 0.878 (0.786–0.969) | <0.0001 | 1.39 | 94.6 | 100 | 97.3% |
| HOTAIR | 0.796 (0.683–0.909) | <0.0001 | 0.68 | 81.5 | 100 | 90.75 |
| GAS5 | 0.939 (0.872–1.000) | <0.0001 | 0.82 | 96.8 | 100 | 98.4 |
|
CVS-NHTN patients vs. control | ||||||
|---|---|---|---|---|---|---|
| LncRNA |
AUC 95% CI |
P-value | Cut-off point | Sensitivity (%) | Specificity (%) | Total accuracy |
| NEAT1 | 0.857 (0.759–0.955) | <0.0001 | 1.33 | 91.2 | 100 | 95.6 |
| HOTAIR | 0.776 (0.659–0.892) | <0.0001 | 0.75 | 75.8 | 100 | 87.9 |
| GAS5 | 0.898 (0.813–0.983) | <0.0001 | 0.84 | 91.9 | 100 | 95.95 |
|
CVS-HTN patients vs. CVS-NHTN patients | ||||||
|---|---|---|---|---|---|---|
| LncRNA |
AUC 95% CI |
p-value | Cut-off point | Sensitivity (%) | Specificity (%) | Total accuracy |
| NEAT1 | 0.585 (0.402–0.715) | 0.455 | 3.83 | 86.4 | 55.95 | 71.17 |
| HOTAIR | 0.562 0.411–0.713) |
0.426 | 0.47 | 65.3 | 59.14 | 62.22 |
| GAS5 | 0.733 (0.603–0.863) | 0.003 | 0.37 | 81.68 | 69.77 | 75.72 |