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. 2022 Nov 23;10(11):e004712. doi: 10.1136/jitc-2022-004712

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Increased CD47 and TSP1 expression within the tumor microenvironment of human melanoma tissue. (A) Representative images of human normal, primary melanoma tumor and metastatic melanoma tumor tissue. (B) CD47 and (C) TSP1 expression was compared between the normal and malignant tumor microenvironment of these tissues. Additionally, (D) CD47 and (E) TSP1 expression was compared in the tumor microenvironment as disease progressed from primary to metastatic tumor. Images were obtained through light microscopy on the Olympus BX43 microscope and analyzed on the PerkinElmer Mantra and inform software. (*p<0.05, n=96–100). TSP1, thrombospondin-1.