Table 3.
Treatment-related adverse events in the two groups.
| TACE+AC (n = 34) | TACE+A (n = 68) | P value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Adverse events | ||||||||||
| Toxicity grade | 1/2 | 3/4 | 1/2 | 3/4 | ||||||
| TACE-related | ||||||||||
| Diarrhea | 6 | 17.6% | 1 | 2.9% | 14 | 20.6% | 5 | 7.4% | 0.268 | |
| Transaminitis | 13 | 38.2% | 3 | 8.8% | 26 | 38.2% | 5 | 7.4% | 1 | |
| Rash | 4 | 63.7% | 0 | 0.0% | 11 | 16.1% | 3 | 4.4% | 0.409 | |
| Nausea with/without vomiting | 22 | 64.7% | 2 | 5.9% | 31 | 45.6% | 5 | 7.4% | 0.135 | |
| Abdominal pain | 19 | 55.9% | 4 | 11.7% | 42 | 61.7% | 9 | 13.2% | 0.641 | |
| Fatigue | 7 | 29.0% | 0 | 0.0% | 4 | 5.8% | 3 | 4.4% | 0.221 | |
| Fever | 19 | 26.5% | 3 | 8.8% | 33 | 48.5% | 0 | 0.0% | 0.144 | |
| Leukopenia | 6 | 17.6% | 1 | 2.9% | 8 | 11.7% | 0 | 0.249 | ||
| Neutropenia | 5 | 14.7% | 1 | 2.9% | 6 | 8.8% | 0 | 0.208 | ||
| Lymphopenia | 4 | 11.8% | 1 | 2.9% | 5 | 7.4% | 1 | 1.5% | 0.499 | |
| Thrombopenia | 7 | 20.6% | 0 | 0.0% | 12 | 17.6% | 0 | 0.0% | 0.789 | |
| Anemia | 6 | 17.6% | 0 | 0.0% | 8 | 11.7% | 0 | 0.0% | 0.543 | |
| Decreased appetite | 6 | 17.6% | 0 | 0.0% | 24 | 35.2% | 0 | 0.0% | 0.071 | |
| Apatinib and Camrelizumab -related | Hand-foot skin reactions | 7 | 11.7% | 3 | 8.8% | 20 | 29.4% | 8 | 11.7% | 0.283 |
| Hypertension | 11 | 32.4% | 4 | 11.7% | 16 | 23.5% | 11 | 16.1% | 0.676 | |
| REECP | 7 | 29.0% | 1 | 2.9% | 0 | 0 | – | |||
| all | 34 | 100.0% | 11 | 32.3% | 64 | 100.0% | 16 | 23.5% | 0.298 | |