TABLE 1.
Clinicopathological characteristics of patients in TCGA, CGGA, REMBRANDT, and WCH cohort.
| Characteristics | TCGA (N = 662) | CGGA (N = 415) | REMBRANDT (N = 369) | WCH (N = 77) |
|---|---|---|---|---|
| Age: mean (range) | 46 (18–89) | 43 (19–76) | 52 (22–87) | 46 (19–77) |
| Gender | ||||
| Female | 282 (42.6%) | 176 (42.4%) | 118 (32.0%) | 30 (39.0%) |
| Male | 380 (57.4%) | 239 (57.6%) | 196 (53.1%) | 47 (77.0%) |
| NA | 0 | 0 | 55 (14.9%) | 0 |
| Histology | ||||
| Astrocytoma | 341 (51.5%) | 182 (43.9%) | 133 (36.0%) | 22 (28.6%) |
| Oligodendroglioma | 167 (25.2%) | 94 (22.7%) | 59 (16.0%) | 21 (27.3%) |
| Glioblastoma | 154 (23.3%) | 139 (33.5%) | 177 (48.0%) | 34 (44.2%) |
| Grade | ||||
| G2 | 214 (32.3%) | 134 (32.3%) | 88 (23.8%) | 29 (37.7%) |
| G3 | 237 (35.8%) | 142 (34.2%) | 66 (17.9%) | 14 (18.2%) |
| G4 | 154 (23.3%) | 139 (33.5%) | 177 (48.0%) | 34 (44.2%) |
| NA | 57 (8.6%) | 0 | 38 (10.3%) | 0 |
| IDH status | ||||
| WT | 236 (35.6%) | 169 (40.7%) | NA | 42 (54.5%) |
| Mutant | 421 (63.6%) | 207 (49.9%) | NA | 35 (45.5%) |
| NA | 5 (0.8%) | 39 (9.4%) | NA | 0 |
| 1p/19q codeletion | ||||
| Non-codel | 488 (73.7%) | 267 (64.3%) | 148 (40.1%) | 43 (55.8%) |
| Codel | 167 (25.2%) | 88 (21.2%) | 24 (6.5%) | 19 (24.7%) |
| NA | 7 (1.1%) | 60 (14.5%) | 197 (53.4%) | 15 (19.5%) |
| TERT promoter status | ||||
| Mutant | 340 (51.4%) | NA | NA | 23 (29.9%) |
| WT | 156 (23.6%) | NA | NA | 30 (39.0%) |
| NA | 166 (25.1%) | NA | NA | 24 (31.2%) |
| MGMT promoter status | ||||
| Unmethylated | 157 (23.7%) | 141 (34.0%) | NA | 13 (16.9%) |
| Methylated | 472 (71.3%) | 195 (47.0%) | NA | 35 (45.5%) |
| NA | 33 (5.0%) | 79 (19.0%) | NA | 29 (37.7%) |
| ATRX status | ||||
| Mutant | 192 (29.0%) | NA | NA | 53 (68.8%) |
| WT | 459 (69.3%) | NA | NA | 22 (28.6%) |
| NA | 11 (1.7%) | NA | NA | 2 (2.6%) |
Abbreviation: TCGA, the cancer genome atlas; CGGA, chinese glioma genome atlas; WCH, west china hospital; IDH, isocitrate dehydrogenase; TERT, telomerase reverse transcriptase; MGMT, O6-methylguanine-DNA, methyltransferase; ATRX, alpha-thalassemia x-linked intellectual disability syndrome; WT, wild type; NA, not available.