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. Author manuscript; available in PMC: 2023 Jul 22.
Published in final edited form as: Circ Res. 2022 Jun 14;131(3):222–235. doi: 10.1161/CIRCRESAHA.121.319817

Figure 7: Ameliorated Vascular Dysfunction, Exercise Intolerance, and Mitochondrial Dysfunction in BT2 Treated 3-MST KO Mice after TAC.

Figure 7:

(A) Aortic vascular reactivity to acetylcholine (Ach), (B) aortic vascular reactivity to sodium nitroprusside (SNP), (C) treadmill running duration in 3-MST KO mice treated with Vehicle or BT2. Respiration using (D) pyruvate or (E) carnitine as substrate and (F) ATP synthesis efficiency in mitochondria isolated from Vehicle or BT2 treated 3-MST KO hearts. Respiration using (G) pyruvate or (H) carnitine as substrate and (I) ATP synthesis efficiency in mitochondria isolated from from Vehicle or BT2 treated 3-MST KO skeletal muscle. Circles inside bars indicates samples size. Data in (A) and (B) were analyzed with ordinary 2-way ANOVA; data in other panels were analyzed with student unpaired 2-tailed t test. Data are presented as mean ± SD.