Fig. 2.

Effect of pre-emptive TIPS vs. drug plus endoscopic treatment on mortality by different risk stratification rules in those with Child-Pugh B cirrhosis.

(A) Cumulative incidence of death in pre-emptive TIPS group vs. medical group stratified by CLIF-C ADs of <48/48-56/>56 (p = 0.74, 0.019 and 0.012, respectively, Gary’s test) (B) active bleeding (p = 0.512 and 0.001, respectively, Gary’s test) and (C) Child B8-9 + AB criteria (p = 0.413 and 0.0011, respectively, Gary’s test) based on competing risk approach (the Fine and Gray method) with liver transplantation being the competing event. Child B8-9 + AB criteria: Low risk: Child-Pugh B without active bleeding and Child-Pugh B7 with active bleeding; High risk: Child-Pugh B8-9 with active bleeding at endoscopy. CLIF-C ADs, Chronic Liver Failure-Consortium acute decompensation score; p-TIPS, pre-emptive transjugular intrahepatic portosystemic shunt.