Fig. 4.

Comparison of different risk stratification rules.

The ROC of the CLIF-C AD score, MELD score, active bleeding at endoscopy and Child B8-9 + AB criteria for predicting (A) 6- week and (B) 1-year mortality. (C) Discrimination of the evaluated models. The concordance-statistic for benefit (c-for-benefit) is a variant of the conventional risk concordance-statistic (c-for-risk) designed to specifically calculate the ability for a model to discriminate between people obtaining more benefit vs. less benefit from a treatment. Note that the c-for-benefit statistic is in general much more conservative than the traditional concordance-statistic, which only assesses the ability of a model to detect higher vs. lower absolute mortality risk, not treatment effect. CLIF-C ADs, Chronic Liver Failure-Consortium acute decompensation score; MELDs, model for end-stage liver disease score; p-TIPS, pre-emptive transjugular intrahepatic portosystemic shunt; ROC, receiver-operating characteristic curve.