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. 2022 Oct 13;63(12):100296. doi: 10.1016/j.jlr.2022.100296

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — Dennd5b^−/− were resistant to diet-induced weight gain regardless of PCSK9 gain-of-function expression. A: Baseline body weights. B: Changes in body weights of wild type and Dennd5b^−/− mice during 3-months feeding a Western diet. Body weights were measured weekly throughout the study. Dennd5b^+/+ n = 4/group and Dennd5b^−/− n = 5/group. Statistical comparisons by two-way ANOVA with Tukey correction for multiple comparisons. ∗P < 0.05 for Dennd5b^+/+ versus Dennd5b^+/+ + PCSK9. # P < 0.05 for Dennd5b^+/+ versus Dennd5b^−/−. PCSK9, proprotein convertase subtilisin/kexin type 9 serine protease; PCSK9, proprotein convertase subtilisin/kexin type 9.