Fig. 2.

Dennd5b^−/− affects plasma PCSK9 concentrations and hepatic LDLR abundance when fed a Western diet. A: PCSK9 was measured by ELISA in wild type and Dennd5b^−/− mouse plasma collected on week 12. B: Hepatic LDLR protein was determined by Western blot on lysates from snap frozen tissue harvested on week 12. Statistical comparisons were performed by two-way ANOVA with Tukey correction for multiple comparisons. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. LDLR, low density lipoprotein receptor; PCSK9, proprotein convertase subtilisin/kexin type 9.