Table 4.
Cox model assessing the impact of postoperative ctDNA status and other characteristics on overall survival.
| Characteristics | Univariate Hazard Ratio [CI 95%] | P value | Multivariate Hazard Ratio* [CI 95%] | P value | |
|---|---|---|---|---|---|
| Age | <60 years 60-69 years ≥70 years | 1 0.92 [0.34-2.46] 1.97 [0.80-4.90] |
0.14 | ||
| Sex | Female Male | 1 1.24 [0.64-2.42] | 0.53 | ||
| Tumor location | Right sided Left-sided Rectal |
1 0.79 [0.38-1.66] 1.23 [0.57-2.69] |
0.53 | ||
| Lymph nodes analyzed | <12 >12 | 1 0.70 [0.34-1.45] | 0.34 | ||
| T stage | T2-3 T4 | 1 1.99 [0.99-4.01] | 0.054 | 1 2.66 [1.26-5.61] | 0.01 |
| VELIPI criteria | None or unknown One or more | 1 1.02 [0.52-1.99] | 0.95 | ||
| Emergency surgery | No Yes | 1 1.31 [0.65-2.63] | 0.45 | ||
| Differentiation | Well or moderate Poor or unknown | 1 2.29 [0.96-5.48] | 0.06 | 1 2.82 [1.15-6.90] | 0.02 |
| Neoadjuvant CRT | No Yes | 1 1.92 [0.88-4.19] | 0.10 | 1 3.12 [1.33-7.34] | 0.01 |
| Adjuvant CT | No Yes | 1 0.87 [0.46-1.67] | 0.69 | ||
| Postoperative ctDNA status | Negative Positive | 1 2.57 [1.07-6.18] | 0.03 | 1 3.15 [1.28-7.74] | 0.01 |
*Multivariate Cox model contains variables with a p value less than 0.1 in univariate analysis. †VELIPI criteria include vascular, lymphatic and/or perineural invasion. CRT, chemoradiotherapy; CT, chemotherapy; ctDNA, circulating tumor DNA.
Bold values correspond to p values lower than 0.05.